The Federal Reserve will disclose a decision just after noon, and Chairman Ben Bernanke is expected to speak at 2:15 p.m. Eastern.
Dow Jones industrial futures are down 13 points to 13,348. The broader S&P futures have given up 1.5 points to 1,438. Nasdaq futures are down 4.75 points to 2,791.50.
There are also some jitters over events in the Middle East. Protesters stormed the U.S. Embassy compound in Yemen's capital Thursday and there is violence around the U.S. mission in Cairo.
The Labor Department releases its weekly unemployment claims report at 8:30 a.m. Eastern.