Republicans now hold seven of the state's 13 Congressional seats. But with the new political boundaries, the GOP could win 10 of the districts.
"The Republicans were able to do redraw so many of these districts, that it's going to make it hard for the Democrats to hold on to seats," said J. Michael Bitzer, a historian and political science professor at Catawba College.
He pointed to North Carolina's 7th, 8th and 11th districts. Democrat Barack Obama carried the districts in 2008. But under the new boundaries, GOP presidential nominee John McCain would have won convincingly in those districts, he said.
The following is a snapshot of the state's other congressional races:
In North Carolina's 1st Congressional District, Democratic incumbent U.S. Rep. G.K. Butterfield is set to square off with Republican challenger Pete DiLauro.
Butterfield, 65, is seeking his fifth two-year term representing the redrawn district.
The district was drawn to favor minority candidates under provisions of the Voting Rights Act. It now includes areas of Durham and spreads east to include pockets of black voters in such towns as Rocky Mount, Goldsboro and Greenville. Democrats have complained the Republican-drawn maps "pack" minority voters into the 1st to make neighboring districts more favorable for GOP candidates.
Still, the heavily Democratic district gives a strong advantage to Butterfield, a member of the Congressional Black Caucus whose father emigrated from Bermuda to Wilson. A graduate of the law school at North Carolina Central University, Butterfield became a judge, including serving a term as a justice on the state Supreme Court.
First elected to Congress in 2004, Butterfield serves on the Energy and Commerce Committee and the Agriculture Committee. He is also an adviser to President Barack Obama's campaign.
DiLauro, the Republican challenger, is a former U.S. Marine and New York City police officer who moved to North Carolina in 1996. According to his campaign website, DiLauro got married at age 17, had three children by age 19 and volunteered to go to Vietnam when he was 20.
After the Marine Corps, DiLauro joined the NYPD in 1975 but was forced to retire after only two years on the job as the result of injuries from an on-duty car accident, according to his campaign. He has since owned a succession of small businesses, including a restaurant and a gas station.
DiLauro's primary political objective is to remove incumbent politicians, according to his website, which features to slogan: "If They're In — Vote Them Out Give Someone Else A Chance."
Butterfield's campaign reported raising more than $800,000 in donations during the current election cycle, while DiLauro has not reported raising any funds, according the Federal Election Commission.
Libertarian candidate Darryl Holloman will also be on the November ballot.
In North Carolina's 2nd Congressional District, Republican U.S. Rep. Renee Ellmers is facing voters for the first time since she was narrowly swept into office during the GOP wave of 2010.
Ellmers, who lives in Dunn, won her seat by defeating longtime Democratic Rep. Bob Etheridge by just 1,483 votes or less than 1 percent of the ballots cast.
A nurse married to a doctor, Ellmers, won a crowded primary fight by campaigning for the repeal of the Affordable Care Act and aligned herself with the then-ascendant tea party movement. She was aided in the general election by the release of a video that showed Etheridge physically confronting two young Republican operatives filming him on a Washington sidewalk.
Now an incumbent, Ellmers, 48, transformed over the last two years into a mainline Republican who has voted with her party's House leadership 95 percent of the time, according to an analysis of the vote database at OpenCongress.org. A Michigan native and mother of a school-age son, Ellmers has also been a frequent guest on political news shows representing the party line and she elected not to join the House Tea Party Caucus.
Her Democratic opponent is Steve Wilkins of Southern Pines. A Durham native, Wilkins retired as a lieutenant colonel after nearly 22 years in the U.S. Army. A combat veteran, he served in the invasion of Grenada, Operation Desert Storm and the Iraq War.
The 2011 redistricting map enacted by the GOP-dominated state legislature last year is expected to help Ellmers, adding more conservative leaning voters to make the 2nd more solidly Republican.
Also on the ballot is Brian Irving, a Libertarian from Cary.
Ellmers has amassed more than $1 million in political contributions during the 2012 election cycle, with $231,405 in cash on hand, according to her financial disclosure report filed with the Federal Election Commission.
In North Carolina's 3rd Congressional district, veteran Republican incumbent U.S. Rep. Walter B. Jones faces Democratic challenger Erik Anderson.
Jones, 69, is seeking a 10th two-year term representing the state's sprawling 3rd District, which includes most of the state's coastline. The son of a longtime Democratic congressman, Jones switched parties to run as a Republican in 1994. He did it after losing in a Democratic Party primary two years earlier in a bid to replace his father in Congress after the elder Jones' death.
Jones and his wife live in Farmville, a small town outside Greenville. Though he has a largely conservative voting record and was a founding member of the House Tea Party Caucus, Jones has repeatedly broken with his party in recent years and voted with Democrats on such issues as raising the minimum wage.
Initially a strong supporter of President Bush's decision to launch the Iraq War, Jones led the charge to rename french fries as "freedom fries" in House cafeteria in protest of the European nation's refusal to supply troops for the invasion. But after no weapons of mass destruction were found, Jones reversed course and in 2005 was one of a handful of congressmen to support calling for the withdrawal of all troops from Iraq.
The 3rd District includes the massive U.S. Marine Corps base at Camp Lejeune. Jones, who served in the N.C. National Guard during the Vietnam War era, is a member of the Armed Services Committee and touts his strong support for the military.
Since taking office, Jones has typically cruised to re-election, winning nearly 72 percent of the vote in 2010. The district lines shifted some last year after being redrawn by the Republican-dominated state legislature but is still expected to favor a conservative candidate.
This year Jones is challenged by former Marine Erik Anderson, a Democrat from Winterville. After leaving the Marines in 2004 with the rank of sergeant, Anderson attended East Carolina University, got married and has managed a large retail store, according to his campaign website.
Anderson is campaigning on improving services for veterans, specifically health care and access to comprehensive job training.
Jones has reported raising $676,992 in political donations in the 2012 election cycle, with $139,168 in cash on hand according to reports filed with the Federal Election Commission. Anderson has raised $18,677 and loaned his campaign $7,878 more, with no reported cash.
For Democratic U.S. Rep. David Price, his first hurdle to re-election came after his district was redrawn.
Price was faced with the prospect of running head-to-head against longtime Democratic Congressman Brad Miller. But Miller stepped aside to let Price run for another two-year term. Price was first elected to Congress in 1986 and represented the 4th District until he lost in 1994. He recaptured the seat two years later and has won every race since then.
A former Duke University public policy professor, Price, 72, is now facing Republican Tim D'Annunzio.
Price has worked to improve public education. He supported successful student aid reform, which reduced student loan interest rates by cutting wasteful subsidies to banks and lending directly to students. The legislation increased the number and size of Pell Grant scholarships and wrote the Price Education Affordability Act, which gives parents and students a tax break on their education loans.
Price also has touted his support for tough new rules for Wall Street to protect consumers from abuses, and authored a new law to help consumers better manage their credit card debt by giving them more information on their statements about the cost of only making the minimum payment.
D'Annunzio, 54, of Raeford, is a conservative Republican businessman who has spoken out against federal spending. A tea party favorite, he ran unsuccessfully for Congress in 2010 in the 8th District.
He has advocated for the defense of the Constitution, and described himself as a Second Amendment advocate.
D'Annunzio believes in eliminating many federal departments and agencies, including the U.S. Department of Education, the Department of Housing and Urban Development and the Environmental Protection Agency.
Price has reported raising $1.09 million in political donations in the 2012 election cycle, with $129,844 in cash on hand, according to reports filed with the Federal Election Commission. D'Annunzio has raised $595,866 with $28,866 in cash on hand.
A fiscal conservative, Republican U.S. Rep. Virginia Foxx is seeking her fifth two-year term in the 5th District.
Her Democratic opponent is political newcomer Elisabeth Motsinger, 55, of Walkertown. She's a physician's assistant and serves on the Winston-Salem/Forsyth County School Board.
Foxx, 69, is a former state senator and community college president from Banner Elk.
She was appointed last year as chair of the U.S. House subcommittee on higher education. She said that quality higher education will be one of the keys to remaining competitive in the global economy. The subcommittee oversees policy on colleges and universities.
An outspoken critic of President Barack Obama, Foxx has opposed most of the administration's initiatives, including the national health care plan and economic stimulus package.
Foxx said the budget deficit has to be reduced by cutting federal spending.
Motsinger said the middle class has to be protected. She says that tax breaks for the wealthy do not lead to job creation.
"Tax breaks on high earners have never led to anything but increasing income inequality. Tax breaks for the top incomes earners will not stimulate our economy," Motsinger said.
She said she believes the federal government plays a major role in education and should determine education standards for all states, with reasonable benchmarks set by "people whose experience is on the ground," including teachers and administrators.
But Foxx said education is not the responsibility of the federal government and should be left up to local and state leaders.
Foxx has reported raising $919,208 in political donations in the 2012 election cycle, with $1.4 million in cash on hand, according to reports filed with the Federal Election Commission. Motsinger has raised $121,471 with $26,594 in cash on hand.
U.S. Rep. Howard Coble, R-Greensboro, who is seeking his 15th term, is being challenged by former Democrat state senator Tony Foriest in the 6th District.
Coble, 81, is a fiscal conservative who wants to repeal President Barack Obama's Affordable Care Act.
North Carolina's longest-serving Republican in the U.S. House says the economy is still faltering. He says he believes that smaller government and lower taxes are the way to create new jobs.
The nation's massive budget deficits also have to be reduced, he says.
First elected to Congress during President Ronald Reagan's administration, Coble opposed the 2009 stimulus package pushed by the Obama administration.
Coble has faced some health problems in recent years. One of the oldest current members of Congress, he had back major surgery in June.
Foriest, 63, of Graham, N.C., worked for the Xerox Corp. for 24 years. He served in the state senate from 2006-2010.
His main focus: creating jobs and improving the economy. He said middle-class families are still struggling.
"My priority is getting our people back to work. The opportunity to feed our families through meaningful employment has to supersede partisan bickering," he said.
He said that many of the federal programs are not only a safety net for "our most vulnerable citizens but many have already been paid for by prudent investors who trust our government to be as good as its promise."
While in the N.C. Senate, Foriest voted for the 2009 Racial Justice Act, which allowed the death penalty to be reduced to life in prison if racism could be proven using statistics. He said he opposed the 2012 rollbacks to the law.
Foriest also knows he is facing an uphill battle against an entrenched incumbent. But he holds out hope that people will vote for change.
Coble has reported raising $492,946 in political donations in the 2012 election cycle, with $162,573 in cash on hand, according to reports filed with the Federal Election Commission. Foriest has raised $40,354 with $19,090 in cash on hand.
The Republican and the Democrat running for North Carolina's open 9th congressional seat agree there's a lot of work that needs to be done to fix the country's economy. But they differ widely on solutions to the problem.
Democratic Mecklenburg County Commissioner Jennifer Roberts, 52, said the U.S. House needs someone willing to work with people across the political spectrum. Republican real estate investor Robert Pittenger, 64, said the solution is someone whose principles are much different than President Barack Obama.
"What has happened over the past 3 ½ years, President Obama and his team has put more impediments in the way of creating jobs," Pittenger said. "My opponent supports those programs."
Pittenger won a bitter Republican primary race. But he has spent $2.8 million during this election, helping him soothe some wounds. Roberts has raised less than $400,000.
The 9th District runs from western Monroe County through southern and western Charlotte north to Iredell County. Forty percent of the district voters registered as Republicans, which is the second highest percentage of the state's 13 congressional districts. Republican Sue Myrick is stepping down after nine terms. She won 69 percent of the vote in 2010.
But Roberts said she thinks many voters in the district are tired of the bickering between political parties and want to vote for someone who will consider results more important than scoring political points.
She points out she was voted as an at-large Mecklenburg County commissioner, which required votes from people in both parties.
"I have voted on the best interest of the whole community while on council," Roberts said.
Pittenger, who served three terms as a state senator before an unsuccessful run for lieutenant governor in 2008, said Roberts supported programs increased the power of county government.
"I believe in the free enterprise system. She believes in big government," Pittenger said.
The two candidates split on an amendment passed earlier this year that defined marriage solely as a union between a man and a woman. Pittenger supported it, while Roberts thinks creating well-paying jobs is more important than legislating who can get married.
"Every minute we spend talking about social issues is a minute we don't spend talking about the economy," Roberts said.
Republican U.S. Rep. Patrick McHenry's reward for winning more than 71 percent of the vote in North Carolina's 10th congressional district was to get most of more liberal-leaning Asheville put into his district.
McHenry, 36, is running for a fifth term in the U.S. House in the district that stretches from Hickory and Gastonia west along the counties that border South Carolina to Polk County before extending into Asheville. His Democratic opponent is 64-year-old Patsy Keever, a North Carolina House member and retired teacher.
McHenry shrugs off any worries about running in a district that voted 63 percent for Republican 2008 presidential candidate John McCain in its old configuration, but 57 percent with its new boundaries drawn in 2011.
"I just like to meet new people," McHenry said.
McHenry's political career began when he ran for a state House seat while at Belmont Abbey College. He was first elected to the U.S. House in 2004.
But Keever said McHenry has extreme positions fed by a lack of experience with problems that regular people face.
"He's young and he hasn't had any world experience. He's either been in the ivory tower or in the legislative bubble all his adult life," she said.
Schools are important to Keever because of her time as an educator. She is against any system that would use vouchers or other benefits for private schools.
McHenry said education isn't the only way he differs from his opponent, saying he also wants to get rid of the health care legislation passed with the support of President Barack Obama. He also wants to see the tax code streamlined so "some of my accountant friends get to actually have time off after Christmas."
"Voters have a very dramatic choice between me and my liberal opponent," McHenry said.
McHenry raised more than $1.1 million through Sept. 30, while Keever has raised just over $440,000.
Ten-term Democratic U.S. Rep. Mel Watts is upset with the way Republican state legislators redrew his 12th District, and it's not because he thinks he is going to lose.
"They poached African-Americans voters into my district to get them out of other people's districts. I'll be disappointed if I don't get 80 percent," Watts said.
Watts is the only congressman in the district that shows up in many places as the definition of a gerrymander. The 12th starts in Charlotte and follows the twists and turns of Interstate 85 up to Greensboro, taking in some predominantly black neighborhoods around Winston-Salem too.
The race might also have the two congressional candidates the furthest apart on the political spectrum. Watts' opponent is Republican and tea party member Jack Brosch. The 54-year-old computer consultant said he is encouraging all voters to look at Watts' positions and see if he remains the right person to represent the district.
Brosch said he has accepted any invitation to campaign including appearing before civil rights organizations and in black churches. He points out his conservative social stances against gay marriage and abortion.
"I think a true Republican message can resonate in this district if people will listen," Brosch said.
Brosch has had to depend on the personal touch. He has raised just about $10,000, while Watts has raised almost $740,000 for his re-election.
Watts won the district in 2010 with almost 64 percent of the vote, and redistricting made it even more Democratic. The district now has 64 percent of its voters registered as Democrats, and 78 percent of them voted for Barack Obama in the 2008 presidential election.
Democrat Charles Malone is feeling much better and running hard to try and win a seat in the U.S. House from the 13th congressional district.
Malone tried to drop out after filing to run because of a health scare. But after getting nearly 67 percent of the votes in the primary and a clean bill of health, Malone, 66, decided to campaign hard against Republican George Holding, a 44-year-old former U.S. attorney, known for his work in getting an indictment against former U.S. Sen. John Edwards.
But Malone is a decided underdog in the 13th, which was redrawn by Republicans to become much easier to win. The district now winds through the northern and eastern Raleigh suburbs, bending back in a rough arc to Wayne County. It no longer includes rural counties along the Virginia state line.
"I keep a map with me all the time. It is contoured strangely," Malone said. "But I've gotten used to it "
The district has been represented by Democrat Brad Miller for five terms. But Miller was drawn into the 4th district and decided not to run, leaving the seat open.
Just 40 percent of the voters in the district in 2008 voted for Republican presidential candidate John McCain. But 54 percent of the voters in the new 13th District voted for McCain.
Holding survived a bruising primary. He is making his first run for political office because he thinks this year's election is crucial to turn the country around before it is too late.
"We're either going to solve the economy in the next four or eight years or we are going to decline," Holding said.
Holding wants to cut taxes and reduce regulation, saying that will help the economy recover faster. His opponent disagrees.
"I stress the healthy and effective balance between government and private sector. Mr. Holding sees government as the problem," said Malone, who is a former newspaper editor and currently works as an equal opportunity officer for the North Carolina Department of Environment and Natural Resources.
Holding is outspending his Democratic opponent 120 times over. He has raised nearly $1.5 million, while Malone has raised just over $15,000.
Mike Biesecker reported from Raleigh and Jeffrey Collins reported from Columbia, S.C.